Lipedema (not to be confused with Lymphedema) is a relatively common although rarely diagnosed connective tissue disease. Lipedema occurs predominantly in Women or those assigned female at birth. Lipedema is characterized by increased nodular and fibrotic adipose tissue on the buttocks, hips and limbs that develops at times of hormone, weight and shape change including puberty, pregnancy, and menopause. Lipedema tissue may be very painful, bruise easily, and can severely impair mobility. Non-lipedema obesity, lymphedema, venous disease, and hypermobile joints are comorbidities. Lipedema tissue is difficult to reduce by diet, exercise, or bariatric surgery.

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